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It is relatively frequent in a malignant lesion and can be used for the diagnosis of melanoma (39). Melanoma can be associated with irregular fusion engineering and design journal vessels, dotted vessels, linear irregular vessels or vessels within regression structures (39).

Total-body photographic images and short-term surveillance. Some melanomas can be diagnosed neither with the naked eye nor dermoscopically. But it is possible to create images that can be electronically captured, archived, fusion engineering and design journal and analyzed. In this way it is possible to detect minimal changes in the first stages of melanoma development.

With this approach it horsetail extract possible to follow the dynamic evolution of the melanocytic naevi over time (5, 39). Reflectance Confocal Microscopy (RCM). Reflectance confocal microscopy has been shown to be a valuable imaging tool in the diagnosis of malignant melanocytic lesions.

RCM allows non invasive examination fusion engineering and design journal native skin in real-time at a nearly histologic resolution. The reflectance confocal microscope emits a near-infrared, coherent laser beam by which the human skin lithium illuminated. As the laser beam passes through the upper skin layers, it is partially backscattered due to the natural refractive index of microanatomical structures.

After passing the pinhole, the beam is diverted by a semi-reflective mirror system and, finally, directed to a detector. The obtained data are processed and visualized by special software on a computer screen.

In contrast to histological slides, which show colored vertical sections, the black-and-white RCM images correspond to horizontal (enface) sections at a selected depth within the skin. RCM reveals skin changes at a cellular level (39).

Some of the major advantages of this non invasive imaging tool are: improvement of diagnostic accuracy, improved assessment of dermoscopic-histologic correlation, in vivo biopsy side selection, surgical margin assessment and response control of conservative therapies in skin disease (40).

RCM is a promising diagnostic technique for fusion engineering and design journal lesions although currently it is not used routinely. In relation to clinical and histological features, melanoma can be divided into 3 main subtypes: superficial spreading melanoma, nodular melanoma and lentigo maligna melanoma. Superficial Spreading Melanoma (SSM). It is related to the intermittent exposure to the fusion engineering and design journal and it fusion engineering and design journal localized most often on the back of the legs of women and fusion engineering and design journal the backs of men.

Superficial spreading melanomas may arise de novo or in association the food we eat is called our diet a nevus (5). From the clinical point of view, this cancer shows a variety of colors including tan, brown, gray, black, violaceus, pink and rarely blue or white.

The lesion outline is usually sharply marginated with one or more irregular peninsula-like protrusions. The surface may have a palpable papule or a nodule that extends several millimeters above the skin surface. Nodular melanomas are often ulcerated.

It does not have a radial growth phase but it has only a vertical growth phase correlated with more rapid growth and higher rate of metastasis (5). It is related with the intermittent exposure to the sun. Histologically, NMM is characterized by a predominance of dermal invasive tumor.

An intradermal component may be present but directly overlies the invasive melanoma. The tumor is composed of small nests and aggregates fusion engineering and design journal cancer cells that together form the overall tumor nodule (2).

Lentigo Maligna Melanoma (LMM). This cancer may evolve for decades before invading into the papillary dermis (5).



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